Predictive Levels of CD24 in Peripheral Blood Leukocytes for the Early Detection of Colorectal Adenomas and Adenocarcinomas.

Dis Markers

The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel ; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel ; Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Published: February 2016

CD24 is expressed in 90% of colorectal adenomas and adenocarcinomas. Colorectal cancer (CRC) can be mostly prevented but average risk population screening by stool testing or colonoscopy faces many hurdles. Blood testing is clinically needed. We aimed to evaluate the utility of CD24 expression in peripheral blood leukocytes (PBLs). Two independent case studies were conducted in eligible individuals undergoing colonoscopy. Protein extracted from PBLs was subjected to immunoblotting using anti-CD24 monoclonal antibodies. CD24 sensitivity and specificity were determined using receiver operating characteristic (ROC) analysis. Initially, 150 subjects were examined: 63 had CRC, 19 had adenomas, and 68 had normal colonoscopies. The sensitivity and specificity of CD24 for distinguishing CRC from normal subjects were 70.5% (95% CI, 54.8-83.2%) and 83.8% (95% CI, 74.6-92.7%) and for adenomas 84.2% (95% CI, 60.4-96.4%) and 73.5% (95% CI, 61.4-83.5%), respectively. In the second trial (n = 149), a similar specificity but higher sensitivity was achieved: 80.0% (95% CI, 63.1-91.6%) for CRC and 89.2% (95% CI, 74.6-97%) for adenomas. A simple noninvasive blood test evaluating CD24 levels has high sensitivity and specificity for detecting colorectal adenomas and cancer in patients undergoing colonoscopy at an urban medical center. Larger multicenter studies are warranted to establish the potential of this promising test.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442284PMC
http://dx.doi.org/10.1155/2015/916098DOI Listing

Publication Analysis

Top Keywords

colorectal adenomas
12
sensitivity specificity
12
peripheral blood
8
blood leukocytes
8
adenomas adenocarcinomas
8
undergoing colonoscopy
8
cd24
6
adenomas
6
95%
6
predictive levels
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!