Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.

Bioorg Med Chem Lett

Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea. Electronic address:

Published: August 2015

Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.081DOI Listing

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  • A study was conducted on a medicinal mushroom, focusing on its beneficial properties attributed to phenolic acids, which have antioxidant and anti-inflammatory effects.
  • Researchers developed a method using ultra-high-performance liquid chromatography with triple quadrupole (UHPLC-QqQ) to accurately measure eight different phenolic acids in the mushroom.
  • The findings showed variation in phenolic acid content among different samples, with specific acids being more abundant, demonstrating the method's effectiveness for quantifying these compounds and enhancing understanding of the mushroom's health benefits.
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