Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.bmcl.2015.05.081 | DOI Listing |
Heliyon
September 2024
School of Food, Jiangsu Food and Pharmaceutical Science College, No.4, Meicheng Road, Higher Education Park, Huai'an City, Jiangsu Province, 223003, China.
This study involved the successful production of mycelial polysaccharides by optimizing submerged culture conditions of Pilát. Then, the investigation focused on the composition and chemical structure of the water-soluble polysaccharide from Pilát mycelia (PBMP) by extraction and purification. Specifically, this study indicated that a water-soluble PBMP fraction 1 (PBMP) was isolated from PBMP.
View Article and Find Full Text PDFJ Fungi (Basel)
February 2024
Department of Food Engineering, Harbin University, Zhongxing Road 109, Nangang District, Harbin 150086, China.
(1) Background: , a valuable medicinal fungus, has limited studies on its gene function due to the lack of a genetic transformation system. (2) Methods: This study aimed to establish an efficient -mediated transformation (ATMT) system for This study involved cloning the promoter (glyceraldehyde-3-phosphate dehydrogenase, ) of , reconstructing the transformation vector, optimizing the treatment of receptor tissues, and inventing a new method for screening positive transformants. (3) Results: The established ATMT system involved replacing the CaMV35S promoter of pCAMBIA-1301 with the promoter of to construct the pCAMBIA-SH- transformation vector.
View Article and Find Full Text PDFNat Prod Res
January 2024
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Bioassay-guided fractionation of the isopropanol extract of the medicinal mushroom led to the isolation and characterisation of a new acorane-type sesquiterpenoid bauminene () and seven known compounds -. The planar structure of was elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR and HR-ESI-MS. The relative configuration of was determined by a combination of ROESY experiment, density functional theory calculation of C NMR, and DP4+ probability analysis, while the absolute configuration of was established by comparative electronic circular dichroism (ECD) spectra analysis.
View Article and Find Full Text PDFPlants (Basel)
October 2023
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Int J Biol Macromol
December 2023
College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:
Colon cancer, a prevalent malignant tumor affecting the digestive system, presents a substantial risk to human health due to its high occurrence and mortality rates. Phellinus baumii polyphenol (PBP), a natural product derived from traditional Chinese medicine, has gained widespread popularity due to its low toxicity and minimal side effects, compared to radiation and chemotherapy. This study used an integrated approach of network pharmacology and experimental verification to elucidate the anti-colon cancer effects of PBP and its potential mechanisms.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!