AI Article Synopsis
- The study investigates how a specific genetic variation (IVS1 -397T>C polymorphism) in the estrogen receptor (ER-α) affects inflammatory responses and complications in boys with type 1 diabetes.
- In a sample of 108 boys with type 1 diabetes and 64 healthy controls, researchers found that boys with the CC genotype exhibited lower levels of blood pressure and inflammatory markers (IL-6 and CRP).
- The results suggest that the -397T allele might be linked to the development of vascular complications in boys with type 1 diabetes before symptoms appear.
Article Abstract
Background And Aims: The effect of estrogens is mediated by activation of estrogen receptors (ERs), which are expressed in many tissues. Because ER-α gene polymorphisms may exert different effects in childhood, in the present study we analyzed associations between the IVS1 -397T>C polymorphism and indicators of inflammatory response as well as late complications in boys with type 1 diabetes mellitus (DM1).
Methods And Results: We examined 108 young boys with DM1 and 64 healthy age-matched control individuals. ER-α genotyping, as well as the CRP and IL-6 serum level and blood pressure, was analyzed. In our study boys with CC genotype had lower blood pressure and IL-6 and CRP serum levels. Similar results were obtained for DM1 boys with microvascular complications - the blood pressure and serum level of IL-6, but not CRP, were still lower in the CC patients.
Conclusions: Our findings suggest that the presence of -397T allele may indicate macro- and microvascular complications in DM1 boys, before the occurrence of first clinical symptoms.
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| http://dx.doi.org/10.1016/j.jdiacomp.2015.05.015 | DOI Listing |
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