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| http://dx.doi.org/10.1111/bcp.12697 | DOI Listing |
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View Article and Find Full Text PDFGRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.
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Department of Molecular, Cellular and Developmental Biology, the University of Michigan, Ann Arbor, MI 48109, USA.
The Golgi apparatus plays a crucial role in the delivery of lysosomal enzymes. Golgi Reassembly Stacking Proteins, GRASP55 and GRASP65, are vital for maintaining Golgi structure and function. GRASP55 depletion results in the missorting and secretion of the lysosomal enzyme cathepsin D (Xiang , 2013), though the mechanisms remain unclear.
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