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A Case of Anatopic Phenomenon in Dapsone Hypersensitivity Syndrome.
Cureus
August 2024
Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Article Synopsis
- A 67-year-old woman with borderline lepromatous leprosy developed dapsone hypersensitivity syndrome, presenting with fever and a red itchy rash, while her leprosy patches remained unaffected.
- Laboratory tests revealed anemia, high white blood cell count, and liver issues.
- After stopping dapsone and starting intravenous dexamethasone, her symptoms improved, and the case highlights the rarely discussed phenomenon of anatopic response, where an infection alters the inflammatory response of a skin condition.
Actinic Granuloma Complicated by Secondary Syphilis: A Case Report.
HCA Healthc J Med
April 2024
Riverside Community Hospital, Riverside, CA.
Introduction: Actinic granuloma (AG) is a rare skin eruption thought to result from a sun-induced inflammatory response attracting giant cells, which are large, multinucleated, and inflammatory, to form granulomas and degrade surrounding elastic material. Clinically, lesions begin on sun-exposed skin as pink papules and nodules that coalesce into demarcated annular plaques with a hypopigmented center. Histologically, actinic elastosis surrounds the outer annulus ring, with histiocytes and giant cells within the raised border, and the innermost central zone is filled with minimal to absent elastic fibers.
View Article and Find Full Text PDFLeukomelanoderma Resembling Hyperpigmented Mycosis Fungoides.
Acta Dermatovenerol Croat
March 2024
Kozo Nakai, MD, PhD, Professor and Chairman, Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan;
Acquired circumscribed hyperpigmented patches and plaques have various differential diagnoses, including post-inflammatory hyperpigmentation and mycosis fungoides (MF). Leukomelanoderma is an uncommon cutaneous condition in which the pathogenesis is not fully elucidated. It has been reported that leukomelanoderma occurs after allergic contact dermatitis from hydroquinone or acute cutaneous graft-versus-host disease (1,2).
View Article and Find Full Text PDFPost-radiation lichen planus: a case report and review of the literature.
J Med Case Rep
March 2024
MSIV, ETSU Quillen College of Medicine, Johnson City, TN, USA.
Background: Lichen planus is a T-cell mediated inflammatory disorder of the skin and mucus membranes and is a rare complication of external beam radiation.
Case Presentation: 64 year old White male who presented to dermatology with a lesion at the lateral aspect of the right thigh. The lesion was first noted 40 years prior and had grown from 1.
Half a Century in Hiding: A Unique Case of Tuberculoid Leprosy with an Unprecedented Incubation Period.
Am J Case Rep
February 2024
Department of Infectious Diseases, Mayo Clinic Florida, Jacksonville, FL, USA.
BACKGROUND Leprosy, also known as Hansen's disease, is a neglected tropical disease with low prevalence in the United States. The disease's long incubation period can cause delayed presentation, and most affected individuals have a history of travel or work in leprosy-endemic regions. The immune response to Mycobacterium leprae determines the clinical characteristics of leprosy, with tuberculoid leprosy being characterized by well-defined granulomas and involvement of peripheral nerves.
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