AI Article Synopsis
- Oxidative imbalance, changes in BDNF levels, and mitochondrial issues are linked to bipolar disorder and its related health problems, like heart disease.
- Carvedilol (CVD), a beta-blocker used for hypertension, has antioxidant and mitochondrial benefits, leading researchers to explore its potential in mitigating mania-like symptoms triggered by lisdexamfetamine (LDX) in male Wistar rats.
- The study found that CVD effectively prevented and reversed behavioral and neurochemical changes caused by LDX, and a combination of CVD and another drug enhanced the overall treatment effect, suggesting a possible antimanic role for CVD in bipolar disorder management.
Article Abstract
Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446493 | PMC |
| http://dx.doi.org/10.1155/2015/692541 | DOI Listing |
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