The vitamin D receptor (VDR) is an important factor in activating immune response in different infectious diseases. The aim of the present study was to investigate the association between the gene polymorphisms and pulmonary tuberculosis (PTB). The case control study was performed on 120 PTB patients and 131 healthy controls. Genetic analysis was performed by polymerase chain reaction and the restriction fragment length polymorphism method. The genotype was associated with TB and the risk of PTB was two times higher in individuals with the genotype. A higher frequency of allele was observed in PTB patients and therefore, the allele may be a risk factor for PTB susceptibility. There were no associations between the and polymorphisms and PTB. In addition, haplotype analysis showed that the and haplotypes ( and ) may have the potential to increase PTB susceptibility. In conclusion, the genotype and allele of the polymorphism were associated with PTB susceptibility. In addition, the and haplotypes may be the susceptible haplotypes for PTB.
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| http://dx.doi.org/10.3892/br.2014.402 | DOI Listing |
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