AI Article Synopsis
- Ticks are major carriers of animal diseases and rank just below mosquitoes for spreading human pathogens.
- Researchers investigated cyclin-dependent kinases (CDKs), which regulate the cell cycle in organisms, as potential targets for anti-tick vaccines.
- Immunization with a specific CDK from the tick species Ixodes persulcatus led to significant reductions in tick feeding and reproduction, suggesting that targeting CDKs could enhance the effectiveness of anti-tick vaccines.
Article Abstract
Among arthropods, ticks lead as vectors of animal diseases and rank second to mosquitoes in transmitting human pathogens. Cyclin-dependent kinases (CDK) participate in cell cycle control in eukaryotes. CDKs are serine/threonine protein kinases and these catalytic subunits are activated or inactivated at specific stages of the cell cycle. To determine the potential of using CDKs as anti-tick vaccine antigens, hamsters were immunized with recombinant Ixodes persulcatus CDK10, followed by a homologous tick challenge. Though it was not exactly unexpected, IpCDK10 vaccination significantly impaired tick blood feeding and fecundity, which manifested as low engorgement weights, poor oviposition, and a reduction in 80% of hatching rates. These findings may underpin the development of more efficacious anti-tick vaccines based on the targeting of cell cycle control proteins.
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| http://dx.doi.org/10.1016/j.vetpar.2015.05.022 | DOI Listing |
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