AI Article Synopsis
- Maternal diabetes is linked to common congenital cardiovascular defects, prompting a study on gene expression in hearts exposed to diabetes during embryonic development.
- Increased levels of hypoxia and the protein HIF-1α were observed in diabetes-exposed hearts at a critical developmental stage (E10.5), along with elevated cardiac Vegfa levels, suggesting potential causes for heart defects.
- Findings indicate that maternal diabetes disrupts the expression of key genes related to heart development and tissue remodeling, potentially affecting heart maturation and outcomes in pregnancies affected by diabetes.
Article Abstract
Cardiovascular defects are one of the most common congenital defects associated with maternal diabetes. Based on whole embryo gene expression microarray analysis, 11 genes were chosen for temporal expression analysis of diabetes-exposed hearts. The majority of the selected genes were deregulated in diabetes-exposed hearts compared to our controls at E13.5, E14.5, and E18.5. We showed increased hypoxia and HIF-1α protein levels in diabetes-exposed hearts at E10.5, which is a critical time point for the induction of developmental defects associated with diabetic embryopathy. Additionally, we found increased cardiac Vegfa levels that might trigger developmental abnormalities associated with diabetic embryopathy. Our results show that maternal diabetes affects the temporal expression pattern of gene encoding molecules involved in heart development and tissue remodelling and that these molecules might affect heart maturation processes and thus, the final outcome of diabetic pregnancies.
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| http://dx.doi.org/10.1016/j.reprotox.2015.06.045 | DOI Listing |
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