AI Article Synopsis
- - The study showed that treating rats with the antioxidant SkQ1 increased levels of the Nrf2 transcription factor and its related antioxidant enzyme genes in blood cells.
- - Specifically, genes encoding key antioxidant enzymes like SOD1, SOD2, CAT, and GPx4 were significantly upregulated with SkQ1 treatment.
- - This increase in gene expression was linked to enhanced activity of several antioxidant enzymes in the rats' leukocytes, suggesting that SkQ1 promotes the body's antioxidant defenses.
Article Abstract
This study demonstrated that pretreatment of rats with mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. The increase in expression of these genes with SkQ1 addition was accompanied by increased activities of catalase, glutathione peroxidase, and glutathione-S-transferase in leukocytes. These results indicate that antioxidant properties of SkQ1 might be realized via induction of expression of the genes regulating activity of antioxidant system elements.
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| http://dx.doi.org/10.1134/S0006297915050107 | DOI Listing |
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