AI Article Synopsis
- Tuberculous meningitis (TBM) is a severe form of tuberculosis with high risks of death and complications, making quick diagnosis and treatment critical.
- A 39-year-old woman showed symptoms like severe headache, fever, and confusion, and after initial treatment failed, a spinal tap confirmed TBM using the GeneXpert assay.
- Starting antitubercular chemotherapy led to her improvement, highlighting the importance of using the GeneXpert test on cerebrospinal fluid for quicker TBM diagnosis.
Article Abstract
Tuberculous meningitis (TBM) remains the most dangerous form of tuberculosis with high mortality and potential complications. The prompt diagnosis and treatment of this condition remains a key for better prognosis. A 39-year-old woman presented with severe headache, fever, nausea and vomiting, with a history of headache for a month. On examination, confusion, neck rigidity, ptosis and upward plantar reflexes were present. After 7 days of empiric treatment without resolution of her symptoms, she had another spinal tap performed. The diagnosis of TBM was performed by the GeneXpert MTB/RIF assay from her cerebrospinal fluid (CSF). Antitubercular chemotherapy was started. The patient subsequently improved. Where available, the GeneXpert assay should be used immediately in CSF samples of patients suspected of TBM as an adjunct to clinical algorithms to increase the chance of a prompt diagnosis and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480084 | PMC |
| http://dx.doi.org/10.1136/bcr-2014-207502 | DOI Listing |
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