Combined Microwave Ablation and Cementoplasty in Patients with Painful Bone Metastases at High Risk of Fracture.

Cardiovasc Intervent Radiol

Department of Oncological Radiology, Oncological Hospital "A. Businco", Regional Referral Center for Oncological Diseases, 09100, Cagliari, Italy.

Published: January 2016

AI Article Synopsis

  • A study evaluated the effectiveness of computed tomography-guided microwave ablation (MWA) combined with cementoplasty for treating painful bone metastases in 35 patients at high risk of fracture.
  • Pain levels were measured before and after treatment, showing significant pain reduction (84% at 1 week, 90% at 1 and 6 months).
  • Additionally, walking ability improved in almost all patients, with no local tumor recurrence or treatment-related fractures observed, indicating that the treatment is both safe and effective.

Article Abstract

Purpose: To retrospectively evaluate the effectiveness of computed tomography-guided percutaneous microwave ablation (MWA) and cementoplasty in patients with painful bone metastases at high risk of fracture.

Materials And Methods: Thirty-five patients with 37 metastatic bone lesions underwent computed tomography-guided MWA combined with cementoplasty (polymethylmethacrylate injection). Vertebrae, femur, and acetabulum were the intervention sites and the primary end point was pain relief. Pain severity was estimated by visual analog scale (VAS) before treatment; 1 week post-treatment; and 1, 6, and 12 months post-treatment. Functional outcome was assessed by improved patient walking ability. Radiological evaluation was performed at baseline and 3 and 12 months post-procedure.

Results: In all patients, pain reduction occurred from the first week after treatment. The mean reduction in the VAS score was 84, 90, 90 % at week 1, month 1, and month 6, respectively. Improved walking ability occurred in 100 and 98 % of cases at the 1- and 6-month functional outcome evaluations, respectively. At the 1-year evaluation, 25 patients were alive, and 10 patients (28 %) had died because of widespread disease. The mean reduction in the VAS score and improvement in surviving patients' walking ability were 90 and 100 %, respectively. No patients showed evidence of local tumor recurrence or progression and pathological fracture in the treated sites.

Conclusion: Our results suggest that MWA combined with osteoplasty is safe and effective when treating painful bone metastases at high risk of fracture. The number of surviving patients at the 1-year evaluation confirms the need for an effective and long-lasting treatment.

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Source
http://dx.doi.org/10.1007/s00270-015-1151-yDOI Listing

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