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N1 derived lipoteichoic acid alleviates insulin resistance in association with modulation of the gut microbiota and amino acid metabolism.
Food Funct
January 2025
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
This study aimed to investigate the effects of heat-killed N1 (HK-N1) and lipoteichoic acid (LTA) derived from it on alleviating insulin resistance by modulating the gut microbiota and amino acid metabolism. High-fat diet (HFD)-fed mice were administered live bacteria or HK-N1, and the results demonstrated that HK-N1 significantly reduced epididymal adipocyte size and serum low density lipoprotein-cholesterol, and improved insulin resistance by increasing the YY peptide and glucagon-like peptide levels. HK-N1 also modulated the gut microbiome composition, enhancing microbiota uniformity and reducing the abundance of , and .
View Article and Find Full Text PDFHypophosphatemia in pregnancy: A case report.
Niger Med J
January 2025
Department of Obstetrics and Gynaecology, AIIMS, Bilaspur, Himachal Pradesh, India.
Autosomal hypophosphatemic rickets though a rare genetic disorder can lead to significant discomfort to the patient resulting in clinical deterioration and a poor quality of life. We describe a case of a 33-year-old woman G2P1001 at 6 weeks of gestation with complaints of myalgia and bony pains. Keeping her history of bony pains and fractures in mind, she was further evaluated.
View Article and Find Full Text PDFCorrelation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors.
J Med Biochem
November 2024
Maternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, China.
Background: Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers.
Methods: 200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented.
Exploring the anti-inflammatory potential of vitamin D in cardiometabolic diseases.
Metabol Open
March 2025
Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Calabash Building, Office no: 02-047 Florida Campus, 1710, South Africa.
The prevalence of cardiometabolic diseases is rising, and this is fuelled by inflammation, which tends to be worse in individuals with vitamin D (VD) deficiency. While non-steroidal anti-inflammatory interventions are available, they present with coagulation events. Hence, alternative therapy in the form of VD supplements is gaining research interest.
View Article and Find Full Text PDFVitamin B6 Alleviates Aflatoxin B1-Induced Impairment of Testis Development by Activating the PI3K/Akt Signaling Pathway.
J Agric Food Chem
January 2025
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266100, China.
Aflatoxin B1 (AFB1) is a harmful environmental contaminant known to disrupt gut microbiota and cause health problems. In recent years, the role of vitamin B6 (VB6) in maintaining intestinal and reproductive health has attracted much attention. AFB1 has been found to damage the intestinal barrier and cause inflammation by disrupting the intestinal microbiota, particularly by increasing the abundance of .
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