AI Article Synopsis
- DNA variations in the fibroblast growth factor 20 gene, particularly the rs12720208 SNP, have been studied for their potential link to Parkinson's disease (PD).
- Previous attempts to replicate the association in various populations were unsuccessful.
- In this study involving 520 PD patients and 520 healthy controls from Iran, significant differences in allele and genotype frequencies were found, indicating that rs12720208 might be a risk factor for PD specifically in the Iranian population.
Article Abstract
DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3'UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p<0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population.
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| http://dx.doi.org/10.1016/j.jns.2015.05.020 | DOI Listing |
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