A Rh-catalyst system based on the asymmetric ligand (t)Bu2PCH2P(o-C6H4OMe)2 is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531818 | PMC |
| http://dx.doi.org/10.1002/anie.201503208 | DOI Listing |
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