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| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129297 | PLOS |
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Beyond nest size: the clinicopathological spectrum of large nested melanocytic tumours and the value of comparative genomic hybridisation and messenger RNA expression analysis.
Pathology
February 2025
Department of Pathology, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, Valencia, Spain; Department of Pathology, University of Valencia Avenida Blasco Ibáñez, Spain. Electronic address:
Large nested melanomas (LNMs) are a rare subtype of naevoid melanoma consisting of large junctional melanocytic nests that are more common in older individuals and/or associated with sun damage. However, the presence of large melanocytic nests alone does not lead to a diagnosis of malignancy, as they can also be found in melanocytic naevi. LNMs are challenging because they lack most classic histological features of malignancy and require thorough clinicopathological evaluation.
View Article and Find Full Text PDFPRAME Is an Effective Tool for the Diagnosis of Nevus-Associated Cutaneous Melanoma.
Cancers (Basel)
January 2024
Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
(1) Background: Nevus-associated cutaneous melanoma (CM) is relatively common in the clinical practice of dermatopathologists. The correct diagnosis and staging of nevus-associated cutaneous melanoma (CM) mainly relies on the correct discrimination between benign and malignant cells. Recently, PRAME has emerged as a promising immunohistochemical marker of malignant melanocytes.
View Article and Find Full Text PDFCorrection: Intrinsic disorder in PRAME and its role in uveal melanoma.
Cell Commun Signal
October 2023
Bascom Palmer Eye Institute, University of Miami, 900 NW 17Th Street, Miami, FL, 33136, USA.
Comparative Analysis of PRAME Expression in 127 Acral and Nail Melanocytic Lesions.
Am J Surg Pathol
May 2022
Department of Pathological Anatomy, Modena University Hospital, Modena, Italy.
PRAME (PReferentially expressed Antigen in MElanoma), a cancer testis antigen expressed in low levels in gonadal, endometrial, and adrenal gland tissues, has been recently considered a valuable tool in the differential diagnosis between benign and malignant melanocytic lesions. The aim of the current study is to perform PRAME immunostaining on a large series of benign and malignant acral lesions to evaluate the reproducibility of data reported in the literature and to validate PRAME as an affordable tool in the differential diagnosis between benign and malignant acral melanocytic tumors. Immunohistochemical analysis for PRAME was performed in 127 benign and malignant acral and nail melanocytic lesions.
View Article and Find Full Text PDFCutaneous Neurocristic Hamartoma Mimicking Basal Cell Carcinoma in a Patient With Xeroderma Pigmentosum.
Am J Dermatopathol
May 2022
Department of Dermatopathology, University of Virginia, Charlottesville, VA.
Neurocristic hamartomas (NCH) of cutaneous origin are especially rare congenital or acquired neoplasms that often arise through aberrant embryologic development of pluripotent neural crest cells. Clinically, they often present as pigmented macules or papules on the scalp with associated alopecia. NCHs are characterized histopathologically by dermal melanocytic, fibroblastic, and neurosustentacular components.
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