AI Article Synopsis
- - Two new sesquiterpenes, sterhirsutins C and D, along with eight other sesquiterpenoid derivatives, were discovered from the fungus Stereum hirsutum.
- - The structure of sterhirsutin C was determined using single-crystal X-ray diffraction, revealing a unique fused ring system.
- - Compounds 1-10 showed cytotoxic effects on certain cancer cell lines, with compound 9 promoting autophagy in HeLa cells and compound 5 inhibiting an immune response in viral-infected cells.
Article Abstract
Two new heterodimeric sesquiterpenes, sterhirsutins C (1) and D (2), along with eight new sesquiterpenoid derivatives, sterhirsutins E--L (3-10), were isolated from the culture of Stereum hirsutum. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possessed an unprecedented chemical skeleton with a 5/5/5/6/9/4 fused ring system. Compound 10 is the first sesquiterpene coupled with a xanthine moiety. Compounds 1-10 showed cytotoxicity against K562 and HCT116 cell lines. Compound 9 induced autophagy in HeLa cells. Compound 5 inhibited the activation of IFNβ promoter in Sendai virus infected cells.
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| http://dx.doi.org/10.1021/acs.orglett.5b01356 | DOI Listing |
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