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Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality.
Nat Hum Behav
January 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and complement systems.
View Article and Find Full Text PDFA randomized cohort study on the use of 3D printed models to enhance surgical training in suturing techniques.
Sci Rep
January 2025
General Surgery, Cancer Center, Department of Hernia Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China.
Three-dimensional (3D) printed surgical models provide an excellent surgical training option to closely mimic real operations to teach medical students who currently rely largely on visual learning aided with simple suturing pads. There is an unmet need to create simple to complex surgical training programs suitable for medical students. A prospective cohort study was conducted on a group of 16 6th year students.
View Article and Find Full Text PDFEffect of implant loading protocols and associated factors on the success rate of implant therapy: A retrospective clinical study.
J Prosthet Dent
January 2025
Assistant Professor, Restorative and Prosthodontic Department, The Ohio State University College of Dentistry, Columbus, OH.
Statement Of Problem: Although immediate implant loading has shown promising clinical results and high survival rates, an increased risk of implant failure and complications has been reported. Achieving consistently predictable outcomes with this approach remains a challenge, but evidence-based guidelines to assist in selecting suitable patients are lacking.
Purpose: The purpose of this retrospective clinical study was to investigate the success rate, survival rate, and complications of immediate implant loading compared with early and delayed loading.
US state minimum wages and rates of maltreatment-related death among children.
Child Abuse Negl
January 2025
Division of Epidemiology, School of Public Health, University of California, 2121 Berkeley Way West, Berkeley, CA 94720, USA; Division of Biostatistics, School of Public Health, University of California, 2121 Berkeley Way West, Berkeley, CA 94720, USA.
Background: The number of U.S. deaths due to child maltreatment (abuse and neglect) has been increasing over several years.
View Article and Find Full Text PDFHuman and entomological determinants of malaria transmission in the Lihir Islands of Papua New Guinea: A cross-sectional study.
PLoS Negl Trop Dis
January 2025
ISGlobal, Barcelona, Spain.
Background: The Lihir Islands of Papua New Guinea, located in an area with high burden of malaria and hosting a large mining operation, offer a unique opportunity to study transmission. There, we investigated human and vector factors influencing malaria transmission.
Methods: In 2019, a cross-sectional study was conducted on 2,914 individuals assessing malaria prevalence through rapid diagnostic tests (RDT), microscopy, and quantitative PCR (qPCR).
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