Drug disposal programs have been seen as a remedy to the concern of environmental contamination resulting from pharmaceutical disposal down the toilet or sink; however a thorough review of peer-reviewed literature and publicly available information on these programs indicates limited research has been conducted to validate the effectiveness of these programs at reducing pharmaceuticals in the environment. The purpose of this research was to determine if drug disposal programs could actually reduce pharmaceutical residues in the environment. The concentration of hydrocodone in wastewater effluent released from a wastewater treatment plant in Denton, Texas was monitored before and after a take back program called Denton Drug Disposal Day (D4). Data collected and analyzed suggests D4 events were successful in contributing to a reduction of pharmaceutical loading to the environment; however there was insufficient evidence to demonstrate that D4 events were exclusively responsible for these improvements.
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http://dx.doi.org/10.1007/s00128-015-1574-9 | DOI Listing |
Subst Use Misuse
January 2025
Tennessee Department of Health, Office of Informatics and Analytics, Nashville, TN, USA.
Background: While illicit substances are commonly involved in the overdose crisis, prescription substances still play a role. Oftentimes, decedents do not have prescriptions for these substances at the time of death. As such, we sought to examine the prevalence of nonmedical drug use in Tennessee through linkage of fatal drug overdose and prescription data.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Earth and Environmental Sciences, University of Illinois at Chicago, Chicago, IL, United States of America.
Municipal solid waste (MSW) landfills represent underexplored microbial ecosystems. Landfills contain variable amounts of antibiotic and construction and demolition (C&D) wastes, which have the potential to alter microbial metabolism due to biocidal or redox active components, and these effects are largely underexplored. To circumvent the challenge of MSW heterogeneity, we conducted a 65-day time series study on simulated MSW microcosms to assess microbiome changes using 16S rRNA sequencing in response to 1) Fe(OH)3 and 2) Na2SO4 to represent redox active components of C&D waste as well as 3) antibiotics.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address:
In order to evaluate the stability of an amorphous solid dispersion (ASD) it is crucial to be able to accurately determine whether the ASD components are homogeneously mixed or not. Several solid-state analysis techniques are at the disposal of the formulation scientist, such as for example modulated differential scanning calorimetry (mDSC) and solid-state nuclear magnetic resonance spectroscopy (ssNMR). ssNMR is a robust, versatile, and accurate analysis technique with a large number of application possibilities.
View Article and Find Full Text PDFWater Environ Res
January 2025
Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA), Centro de Investigación en Alimentación y Desarrollo (CIAD), Culiacán, Sinaloa, Mexico.
The reliance on agriculture in many nations has increased the use of treated wastewater for irrigation. However, reclaimed water still poses health risks from resistant pathogens like Cryptosporidium spp. Ozone, a strong disinfectant, has been used in water treatment.
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
Department of Botany, Bacha Khan University, Charsadda, Charsadda, 24420, Khyber Pakhtunkhwa, Pakistan.
Wastewater is commonly contaminated with many pharmaceutical pollutants, so an efficient purification method is required for their removal from wastewater. In this regard, an innovative tertiary Se/SnO@CMC/Fe-GA nanocomposite was synthesized through encapsulation of metal organic frameworks (Fe-glutaric acid) onto Se/SnO-embedded-sodium carboxy methyl cellulose matrix to thoroughly evaluate its effectiveness for adsorption of levofloxacin drug from wastewater. The prepared Se/SnO@CMC/Fe-GA nanocomposite was analyzed via UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermo gravimetric analysis (TGA), energy dispersive X-ray (EDX), and X-ray diffraction (XRD) to valuate optical property, size, morphology, thermal stability, and chemical composition.
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