AI Article Synopsis
- NSAIDs often trigger hypersensitivity drug reactions, particularly in patients with NSAID-exacerbated respiratory disease (NERD).
- This study analyzed genetic variants in arachidonic acid metabolism genes among 250 NERD patients, 260 NSAID-tolerant asthmatics, and 315 healthy controls.
- Significant genetic associations with NERD were found, revealing potential pathways for understanding the disease and aiding in the development of predictive tests.
Article Abstract
Aim: NSAIDs are the most frequent cause of hypersensitivity drug reactions. We have examined the association between NSAID-exacerbated respiratory disease (NERD) and genetic variants in arachidonic acid metabolism genes.
Patients & Methods: We included 250 NERD patients, 260 NSAID-tolerant asthmatic (NTA) subjects and 315 healthy controls.
Results: Significant associations with NERD were identified for: ALOX15 rs3892408 C/C homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011), PTGS-1 rs5789 A/A homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011), PTGS-1 rs10306135 A/A homozygous genotype (NERD vs NTA; p = 0.0009, pc = 0.0091; NERD vs controls; p = 0.0064, pc = 0.045). Differences in ALOX5 copy number variations were also found (NERD vs NTA; p = 0.010; NERD vs controls; p = 0.0001).
Conclusion: These results improve our understanding of the underlying mechanisms of NERD and may help develop a predictive test for this pathology. Original submitted 3 November 2014; Revision submitted 2 April 2015.
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| http://dx.doi.org/10.2217/pgs.15.43 | DOI Listing |
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