Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression.

Boadie W Dunlop Mary E Kelley Callie L McGrath W Edward Craighead Helen S Mayberg

J Neuropsychiatry Clin Neurosci

From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).

Published: May 2016

A putative right anterior insula metabolism biomarker predictive of treatment outcomes was retrospectively applied to 30 depressed psychotherapy--or escitalopram-treated nonremitters who entered combination treatment. Patients whose added treatment matched the biomarker-indicated treatment remitted more often than biomarker-mismatched patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788472	PMC
http://dx.doi.org/10.1176/appi.neuropsych.14030048	DOI Listing

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