AI Article Synopsis
- Trophoblast HLA-C antigens from the father are seen as semi-allografts that can activate maternal immune responses, particularly through maternal antigen-presenting cells (APCs).
- Maternal CD4+ T helper cells respond to these antigens by producing different cytokines, leading to the classification of these cells into Th1, Th2, and Th17 types.
- Th1 and Th17 cells are linked to miscarriage due to acute allograft rejection, while Th2 and regulatory CD4+ T cells promote allograft tolerance, which is crucial for successful pregnancies.
Article Abstract
Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsible for acute allograft rejection, could be involved in miscarriage and Th2 cells together with regulatory CD4+ T cells, known to be involved in allograft tolerance, could be responsible, at least in part, for the success of pregnancy. In this review we focus the role effector CD4+ T cells Th1, Th2 and Th17 cells on the fetal allograft tolerance.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461901 | PMC |
| http://dx.doi.org/10.1186/s12948-015-0015-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!