Drug resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum extensively drug-resistant (XXDR) tuberculosis showing resistance to most first- and second-line agents. The results of a correlation of whole-genome sequencing (WGS) and phenotypic testing were discordant, suggesting that overreliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508398 | PMC |
| http://dx.doi.org/10.1128/JCM.00891-15 | DOI Listing |
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