AI Article Synopsis
- Scientists created new chiral ligands called spiro P-N-S ligands (SpiroSAP) and made iridium complexes using them.
- By adding a 1,3-dithiane group to these ligands, they developed an effective chiral iridium catalyst.
- This catalyst was successful in asymmetric hydrogenation of β-alkyl-β-ketoesters, yielding chiral β-alkyl-β-hydroxyesters with very high enantioselectivities (95-99.9% ee) and impressive turnover numbers (up to 355,000).
Article Abstract
The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of β-alkyl-β-ketoesters, producing chiral β-alkyl-β-hydroxyesters with excellent enantioselectivities (95-99.9% ee) and turnover numbers of up to 355,000.
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| http://dx.doi.org/10.1002/anie.201502860 | DOI Listing |
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