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Disposable and sensitive electrochemical magneto-immunosensor for point-of-care HCV diagnostics: Targeting HCVcAg, the active viremia biomarker, in patient samples.
Biosens Bioelectron
December 2024
Centre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, United Kingdom. Electronic address:
Early detection of hepatitis C virus (HCV) infection is crucial for eliminating this silent killer, especially in resource-limited settings. HCV core antigen (HCVcAg) represents a promising alternative to the current "gold standard" HCV RNA assays as an active viremia biomarker. Herein, a highly sensitive electrochemical magneto-immunosensor for the HCVcAg was developed.
View Article and Find Full Text PDF20∗20∗60: A multilevel climate change analysis framework.
J Environ Manage
January 2025
Centro Studi PLINIVS, University of Naples Federico II, 80134, Naples, Italy; Department of Architecture, University of Naples Federico II, 80134, Naples, Italy. Electronic address:
Cities worldwide have established plans and policies to achieve climate-neutral and climate-resilient objectives in recent decades. Researches have demonstrated that Climate Change Action Plans generally fail to include mitigation and adaptation approaches in their planning processes, despite their importance. A proposed multilevel assessment of Climate Change Action Plans, urban regeneration, and building projects was used to analyze the ten cities most sustainable in terms of developing environmental strategies, including local climate action to determine the degree of adaptation and mitigation integration in cutting-edge contexts and to identify measures that show synergies and co-benefits for urban design practices.
View Article and Find Full Text PDFMachine-learning derived identification of prognostic signature to forecast head and neck squamous cell carcinoma prognosis and drug response.
Front Immunol
January 2025
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Introduction: Head and neck squamous cell carcinoma (HNSCC), a highly heterogeneous malignancy is often associated with unfavorable prognosis. Due to its unique anatomical position and the absence of effective early inspection methods, surgical intervention alone is frequently inadequate for achieving complete remission. Therefore, the identification of reliable biomarker is crucial to enhance the accuracy of screening and treatment strategies for HNSCC.
View Article and Find Full Text PDFSafety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial.
Exp Hematol Oncol
January 2025
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China.
Background: Due to the lack of effective treatment options, the prognosis of patients with relapsed/refractory acute myeloid leukemia (R/R AML) remains poor. Although chimeric antigen receptor (CAR)-T-cell therapy has shown promising effects in acute lymphoblastic leukemia (ALL) and lymphoma, its application in R/R AML is limited by "off-target" effects, which lead to severe bone marrow suppression and limit its clinical application. CAR-natural killer (NK) cells not only exhibit antitumor effects but also demonstrate increased safety and universality.
View Article and Find Full Text PDFOrbital reactive lymphoid hyperplasia: Case series and literature review.
Eur J Ophthalmol
January 2025
Liverpool University Hospitals NHS Foundation Trust, University of Liverpool, Liverpool, UK.
This study aimed to describe a case series of patients diagnosed with orbital reactive lymphoid hyperplasia (RLH) at a single tertiary care centre. A retrospective review was conducted by searching electronic medical records at Liverpool University NHS Foundation Trust (LUHFT) from 1 December 2021 - 1 December 2023, to identify all patients with a histological diagnosis. Ten patients with an orbital histological diagnosis of RLH were identified.
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