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Factors Associated with Retention in HIV Care within 12 months Postpartum: A Retrospective Cohort Study.
J Acquir Immune Defic Syndr
January 2025
Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics.
Background: Loss to follow-up to HIV care following delivery puts birthing parents with HIV at higher risk of loss of viral suppression, disease progression, and HIV partner transmission. This study assessed factors associated with retention in postpartum HIV care.
Methods: This is a retrospective cohort study at a single academic medical center and included patients followed from January 2014 to December 2022.
Dexmedetomidine Regulates Macrophage Phenotype Remodeling Through AMPK/SIRT1 to Alleviate Inflammatory Mediators and Lung Injury.
J Biochem Mol Toxicol
January 2025
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality in the intensive care unit (ICU) and can cause excessive inflammation. Dexmedetomidine (DEX) is a drug that exerts anti-inflammatory effects. Identifying the anti-inflammatory mechanism of DEX in the context of ALI/ARDS possesses potential significance for the prevention and treatment of ARDS.
View Article and Find Full Text PDFUniversity student perspectives on antimicrobial peptide use in farm animals.
PLoS One
December 2024
W. Maurice Young Centre for Applied Ethics, School of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
Growing awareness of antimicrobial resistance (AMR) in livestock production has led to calls for the development of alternatives such as antimicrobial peptides (AMPs) that are also able to combat infectious diseases in farm animals. A critical step in the development of AMPs is to understand people's perspectives towards this technology to avoid misalignment with societal expectations. The aim of this study was to investigate university student perspectives of AMP applications in farm animals as alternatives to antibiotic use.
View Article and Find Full Text PDFNaphthoquinone-derived ZSW-4B induces apoptosis in triple-negative breast cancer via AMPK signalling activation.
Sci Rep
November 2024
Department of Biochemistry and Molecular Biology, School of Life Sciences, Xiangya School of Medicine, Central South University, Changsha, 410008, China.
Article Synopsis
- Triple-negative breast cancer (TNBC) is highly aggressive and associated with poor outcomes, highlighting the need for effective treatments.
- The compound ZSW-4B shows promise in selectively inhibiting TNBC cell growth by inducing apoptosis, as confirmed by various experimental models.
- It activates the AMPK signaling pathway, and knocking out AMPK reverses ZSW-4B's anti-tumor effects, suggesting AMPK's crucial role in this process.
Hiding Uncertain Me in the Crowd: Avoidance-Oriented Affiliation Defense to Self-Uncertainty.
Psychol Res Behav Manag
November 2024
Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, Beijing, People's Republic of China.
Purpose: This study explored how individuals cope with self-uncertainty by subconsciously affiliating with groups. Specifically, we investigated whether this affiliation is driven by avoiding isolation rather than pursuing group identity or entitativity.
Methods: In Study 1, we recruited 50 undergraduate students and employed the Affect Misattribution Procedure (AMP) to measure implicit attitudes toward affiliation and isolation after inducing self-uncertainty.
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