AI Article Synopsis
- The study investigates the role of vaspin, an adipokine related to obesity and insulin sensitivity, on resting metabolic rate (RMR) in obese individuals.
- The research involved 222 obese participants, measuring body composition, RMR via indirect calorimetry, and serum vaspin levels through an enzyme-linked immunosorbent assay.
- Results indicated that higher circulating vaspin levels are associated with higher RMR, particularly among women, but dietary intake did not differ significantly between groups based on vaspin levels.
Article Abstract
Background/objective: Vaspin is a recently identified adipokine related to obesity and insulin sensitivity. The precise mechanism of vaspin in the body is not well known, and its function in resting metabolic rate (RMR) is even less understood. Therefore, the main aim of this study was to investigate the effect of circulating vaspin on RMR in obese people.
Materials And Methods: A total of 222 obese participants were included in the current comparative cross-sectional study. Body composition was measured using body composition analyzer. RMR was measured by means of indirect calorimetry. For the measurement of vaspin serum concentrations, an enzyme-linked immunosorbent assay was used. Dietary intake was assessed using 3-day 24-h dietary recall.
Results: Between low and high circulating vaspin groups, there was significant difference for sex (P = 0.03), fat percent (P = 0.008), RMR per weight (P < 0.001), and RMR per fat free mass (FFM) (P = 0.007). However, there was no statistical difference between the groups in dietary intake after adjustment for energy intake (P > 0.05). Furthermore, individuals with higher level of RMR had higher vaspin concentration. Weight, visceral fat, FFM, and fat mass had significant effect on increasing RMR (P < 0.05) but after adding vaspin as a covariate in the general linear model; visceral fat (P = 0.078) and fat mass (P = 0.339) missed their effectiveness.
Conclusion: Circulating vaspin level is higher in women than in men in obese individuals. Moreover, it was found that vaspin had mediator effect between visceral fat and fat mass associations with RMR in obese participants.
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| http://dx.doi.org/10.1007/s00394-015-0948-4 | DOI Listing |
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