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A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.
Clin Pharmacokinet
December 2024
Department of Anesthesiology, University of Groningen, University Medical Center Groningen, P. O. Box 30001, 9700 RB, Groningen, The Netherlands.
Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.
View Article and Find Full Text PDFGreen criminology in Malaysia's palm oil industry: deforestation, ecological footprints, and corporate environmental responsibility.
Environ Sci Pollut Res Int
December 2024
Accounting Research Institute (ARI HICoE) & Faculty of Accountancy, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia.
This research employs the treadmill of production (ToP) and legitimacy theories to examine the relationship between deforestation, ecological footprints, and corporate environmental responsibility (CER) in the context of green criminology within the Malaysian palm oil industry. The study employs a regression analysis to assess the connection between deforestation (total palm oil-planted hectares) and ecological footprints data spanning 2008 to 2018. Additionally, content analysis investigates the CER practices of 40 palm oil companies listed on Bursa Malaysia between 2016 and 2019.
View Article and Find Full Text PDFCoγ activation of Cladophora rupestris biomass functional groups and its effect on Pb adsorption.
Environ Sci Pollut Res Int
December 2024
Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei, 230036, People's Republic of China.
To investigate the modification of Pb adsorption of the functional groups of Cladophora rupestris (C. rupestris) biomass by gamma radiation (Coγ-ray), the interface structure, chemical properties, adsorption behaviors, and Pb adsorption mechanisms of C. rupestris biomass were investigated after irradiation with varying doses of Coγ-ray.
View Article and Find Full Text PDFSystematic review: Mechanisms of photoactive nanocarriers for imaging and therapy including controlled drug delivery.
Eur J Nucl Med Mol Imaging
December 2024
Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Background: The design of smart, photoactivated nanomaterials for targeted drug delivery systems (DDS) has garnered significant research interest due in part to the ability of light to precisely control drug release in specific cells or tissues with high spatial and temporal resolution. The development of effective light-triggered DDS involves mechanisms including photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photorearrangement, which permit response to ultraviolet (UV), visible (Vis), and/or Near Infrared (NIR) light. This review explores recent advancements in light-responsive small molecules, polymers, and nanocarriers, detailing their underlying mechanisms and utility for drug delivery and/or imaging.
View Article and Find Full Text PDFA cross-sectional and longitudinal evaluation of serum creatinine as a biomarker in spinal muscular atrophy.
Orphanet J Rare Dis
December 2024
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei province, China.
Objective: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by proximal muscle weakness and atrophy. The increasing availability of disease-modifying therapies has prompted the development of biomarkers to facilitate clinical assessments. We explored the association between disease severity and serum creatinine (Crn) levels in SMA patients undergoing up to two years of treatment with nusinersen.
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