Seven patients having repeated inflammatory relapses of herpes simplex keratitis have been treated by small dosages of steroid eyedrops (from 0.25% prednisolone once a week to 1% prednisolone once a day). In these patients these doses were almost always sufficient. There was no complications (especially there happened 7 intercurrent dendritic ulcers which were unaffected by the steroids).
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J Therm Biol
May 2020
Department of Wildlife and Fisheries Sciences, Texas A&M University, TAMU, 2258 Bldg. 1537, 534 John Kimbrough Blvd., College Station, TX 77843, USA.
We tested the concept that moose (Alces alces) begin to show signs of thermal stress at ambient air temperatures as low as 14 °C. We determined the response of Alaskan female moose to environmental conditions from May through September by measuring core body temperature, heart rate, respiration rate, rate of heat loss from exhaled air, skin temperature, and fecal and salivary glucocorticoids. Seasonal and daily patterns in moose body temperature did not passively follow the same patterns as environmental variables.
View Article and Find Full Text PDFJ Phys Chem B
June 2009
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
The inclusion of hydrocortisone, progesterone, and testosterone into the cavity of beta-cyclodextrin (beta-CD) following two possible orientations was investigated using molecular dynamics simulations and free-energy calculations. The free-energy profiles that delineate the inclusion process were determined using an adaptive biasing force. The present results reveal that although the free-energy surfaces feature two local minima corresponding to a partial and a complete inclusion, the former mode is markedly preferred, irrespective of the orientation.
View Article and Find Full Text PDFGenes Brain Behav
July 2008
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Neuropeptide Y (NPY) acting through Y1 receptors reduces anxiety- and depression-like behavior in rodents, whereas Y2 receptor stimulation has the opposite effect. This study addressed the implication of Y4 receptors in emotional behavior by comparing female germ line Y4 knockout (Y4-/-) mice with control and germ line Y2-/- animals. Anxiety- and depression-like behavior was assessed with the open field (OF), elevated plus maze (EPM), stress-induced hyperthermia (SIH) and tail suspension tests (TST), respectively.
View Article and Find Full Text PDFRev Neurol (Paris)
May 2006
Service de Neurologie et Explorations Fonctionnelles, CHU ibn Rochd, Casablanca, Maroc.
Introduction: Hypokalaemic periodic paralysis can be primitive or secondary to potassium deficiency which can arise from several causes. Primary Sjogren's syndrome is a rare cause related to kidney involvement.
Case Report: A 50-year-old woman has been admitted for hypotonic tetraparesis which had appeared a few days earlier.
Steroids
July 2006
Laboratorio de Química Hormonal, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70-228, México D.F. 04510, México.
The present paper describes a theoretical approach to the catalytic reaction mechanism involved in the conversion of 5-androstene-3,17-dione to 4-androstene-3,17-dione. The model incorporates the side chains of the residues tyrosine (Tyr(14)), aspartate (Asp(38)) and aspartic acid (Asp(99)) of the enzyme Delta(5)-3-ketosteroid isomerase (KSI; EC 5.3.
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