Seventeen captive Nubian ibex (Capra nubiana) were immobilized for transportation and/or hoof trimming, deworming, and vaccinations. Of these, 11 were immobilized with a combination of butorphanol (0.13±0.03 mg/kg), midazolam (0.13±0.03 mg/kg), and medetomidine (0.13±0.03 mg/kg) (BMM), and 6 were immobilized with a combination of butorphanol (0.11±0.03 mg/kg), azaperone (0.22±0.06 mg/kg), and medetomidine (0.11±0.03 mg/kg) (BAM) by intramuscular injection. Induction and recovery times were recorded. Heart rate, respiratory rate, rectal temperature, blood pressure, and oxygen saturation were measured. The quality of induction, immobilization, and recovery were scored (scale 1-5; 1=poor, 5=excellent). Mean induction time was significantly shorter in the BMM group versus the BAM group (8.8±2.7 and 20.1±7.8 min, respectively). Median induction score and median immobilization score were significantly higher (i.e., better) in the BMM group than the BAM group (5 versus 2.5 and 4 versus 3, respectively). The mean and diastolic blood pressures were significantly higher in the BMM group at the 25-min time point. Atipamezole was administered at the end of procedures, and all ibex recovered smoothly. Mean recovery time was significantly longer in the BMM group versus the BAM group (9.5±4.3 and 3.3±2.2, respectively). In conclusion, at the doses used, the combination of BMM was superior to BAM for short-term immobilization in captive Nubian ibex.
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http://dx.doi.org/10.1638/2014-0202R1.1 | DOI Listing |
Sci Total Environ
January 2025
Institute of Estuarine and Coastal Research, School of Marine Engineering and Technology, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:
With climate change and intensified human activities, disasters such as heavy rainfall, flooding, typhoons, and storm surges are becoming more frequent, posing significant threats to lives, property, and economic development. We propose a method combining extreme value theory and probability distribution to examine the flood severity under the effect of strong human activities. By focusing on the Pearl River Delta (PRD), as one of the most populated areas of China, we quantified changes in the severity of extreme water level for different return levels between 1966 and 1990 and 1991-2016 (with strong human activities), associated with the spatial patterns over the PRD.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
January 2025
From the Department of Surgery, University of Minnesota Medical School (M.S., K.S.); Department of Surgery (E.K.J., D.M., J.M.-D.), University of Minnesota; Fairview Health Services, Trauma Services, (M.B., M.D.); and Department of Surgery (G.B.M.-M., C.J.T.), Institute for Health Informatics (G.B.M.-M., C.T.), and Center for Learning Health System Sciences (G.B.M.-M., C.T.), University of Minnesota, Minneapolis, Minnesota.
Lancet Child Adolesc Health
December 2024
Department of Pediatrics, University of Ottawa and Children's Hospital of Eastern Ontario and Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Paediatric critical care units are designed for children at a vulnerable stage of development, yet the evidence base for practice and policy in paediatric critical care remains scarce. In this Health Policy, we present a roadmap providing strategic guidance for international paediatric critical care trials. We convened a multidisciplinary group of 32 paediatric critical care experts from six continents representing paediatric critical care research networks and groups.
View Article and Find Full Text PDFMol Biol Rep
December 2024
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 15468-15514, Tehran, Iran.
Background: The progression of leukemia is substantially associated with the interactions of leukemic cells with surrounding cells within the bone marrow microenvironment (BMM), and these interactions were facilitated using exosomes as vital mediators. The current study aimed to examine the proliferative effects of exosomes derived from the HL-60 cell line, a representative of acute myeloblastic leukemia (AML), on the cell cycle progression of human bone marrow mesenchymal stromal cells (hBM-MSCs), a key element of the BMM.
Methods And Results: hBM-MSCs were treated with different concentrations of AML-derived exosomes from the HL-60 cell line.
Introduction: Hypophosphatasia is a rare inherited systemic metabolic disorder, with an estimated prevalence in the severe forms of the disease of 1/100.000-1/300.000, that affects the typical architecture of bone, leading to defective mineralization during growth and remodeling.
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