AI Article Synopsis
- A new method has been created to synthesize 2-aminobenzimidazoles or 2-aminoquinazolines using cyanamides, arylboronic acids, and amines.
- The process is simple and involves oxidative conditions with specific catalysts (CuCl2·2H2O and 2,2'-bipyridine) and K2CO3, conducted under an oxygen atmosphere.
- This synthesis allows for the quick formation of key compounds by creating three new bonds, including two C-N bonds and one C-H functionalization bond.
Article Abstract
A copper-promoted three-component synthesis of 2-aminobenzimidazoles (1) or of 2-aminoquinazolines (2) involving cyanamides, arylboronic acids, and amines has been developed. The operationally simple oxidative process, performed in the presence of K2CO3, a catalytic amount of CuCl2·2H2O, 2,2'-bipyridine, and an O2 atmosphere (1 atm), allows the rapid assembly of either benzimidazoles or quinazolines starting from aryl- or benzyl-substituted cyanamides, respectively. In this process, the copper promotes the formation of three bonds, two C-N bonds, and an additional bond resulting from C-H functionalization event.
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| http://dx.doi.org/10.1021/acs.joc.5b00614 | DOI Listing |
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