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Isolated Langerhans cell histiocytosis of the stomach in adults: An analysis of clinicopathologic characteristics and molecular genetics.
Medicine (Baltimore)
December 2024
Department of Gastroenterology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
Isolated gastric Langerhans cell histiocytosis (LCH) occurs extremely rarely in adults. We characterized the clinicopathological and molecular genetics of this rare entity. We retrospectively analyzed the clinicopathologic and prognostic features of 3 patients with isolated gastric LCH during the past 10 years, with a review of an additional 20 patients from the literature.
View Article and Find Full Text PDFInitial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet Cell Protection by Salmon-Derived Bioactive Peptides.
Mar Drugs
October 2024
HBC Immunology Inc., Menlo Park, CA 2043, USA.
This study examines the in vitro effects of a soluble protein hydrolysate (SPH) derived from Atlantic salmon (Salmo salar) on incretin receptor activity and pancreatic islet cell protection to explore the mechanisms underlying SPH's observed benefits on weight loss and metabolic health in overweight individuals. SPH demonstrated a dose-dependent enhancement of glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptor activity, with significant increases of 2.4-fold ( < 0.
View Article and Find Full Text PDFThe prevalence of depression and anxiety in patients with metastatic disease to the spine.
J Craniovertebr Junction Spine
September 2024
Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Article Synopsis
- The study highlights that about 20% of patients with metastatic spine disease experience depression, while approximately 17% struggle with anxiety, emphasizing the need for mental health awareness in this population.
- Data was collected from patients over 18 years old who underwent treatment for metastatic spinal disease from 2017 to 2022, revealing a significant number of both depression and anxiety diagnoses among them.
- The findings suggest that spine surgeons should actively screen for mental health issues in patients with spinal metastases to ensure timely referrals for psychological support.
Manifestations and outcomes of digestive tract involvement in adult Langerhans cell histiocytosis.
Ann Hematol
November 2024
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Article Synopsis
- Langerhans cell histiocytosis (LCH) is a rare condition involving the growth of Langerhans cells, with digestive tract involvement noted in about 2.80% of cases; this study looks at 13 adult patients confirmed to have gastrointestinal LCH (LCH-GI).
- Of the patients, 53.8% had unifocal lesions while 46.2% had multisystem disease; symptoms varied, with some having no gastrointestinal symptoms at diagnosis, and the stomach was the most commonly affected organ.
- Genetic analysis revealed BRAF mutations in 62.5% of patients, and those with certain types of lesions had better progression-free survival; the study underscores the need for end
Ectopic Pancreatic Tissue in the Gallbladder.
Ochsner J
January 2024
Department of General Surgery, Government Medical College and Hospital, Chandigarh, India.
Ectopic pancreatic tissue, also referred to as heterotopic pancreas, is defined as the presence of pancreatic tissue in an organ outside the pancreas. Ectopic pancreatic tissue, a rare embryologic abnormality, has been reported in the stomach, duodenum, colon, and Meckel diverticulum and is usually discovered incidentally. We report a case of ectopic pancreatic tissue in the gallbladder of a 37-year-old female who underwent a cholecystectomy after a clinical diagnosis of chronic cholecystitis.
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