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| http://dx.doi.org/10.1136/bcr-2014-209170 | DOI Listing |
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Lamotrigine induced drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with eosinophilic pan-colitis, cholestasis and cytomegalovirus reactivation.
Rev Esp Enferm Dig
September 2024
Gastroenterología y Endoscopia Digestiva, Hospital Universitario Dr. José Eleuterio González, México.
The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is an idiosyncratic drug-induced reaction that primarily affects the liver, lungs, and kidneys. While several organs are commonly involved, the incidence of DRESS affecting the gastrointestinal tract is rarely reported. We present a 72-year-old man with a history of epilepsy who developed DRESS syndrome manifested by eosinophilic pancolitis, cholestasis, and reactivation of cytomegalovirus (CMV) following the initiation of lamotrigine.
View Article and Find Full Text PDFAcute kidney injury in lamotrigine-induced DRESS syndrome.
Pediatr Nephrol
November 2024
Klinik Für Pädiatrie m. S. Gastroenterologie, Nephrologie Und Stoffwechselmedizin, Charité Universitätsklinikum, Berlin, Germany.
We present a case of lamotrigine-triggered DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome with acute kidney injury stage 3. A 17-year-old girl with known epilepsy treated with lamotrigine presented with acute kidney injury as well as skin eruption, fever, and apathy. Extended diagnostics, considering infectious and autoimmune diseases, remained unremarkable.
View Article and Find Full Text PDFUnraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
Pharmacogenet Genomics
July 2024
Department of Pain Medicine, Singapore General Hospital, Singapore.
Article Synopsis
- This umbrella review investigates the link between the HLA-B*1502 gene and the development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients taking certain antiepileptic medications.
- A thorough search of Pubmed, Scopus, and EMBASE was conducted to gather relevant studies, which included systematic reviews, meta-analyses, and case-control studies assessing the HLA-B*1502 allele’s impact on various antiepileptics.
- The review concludes that while the HLA-B*1502 allele poses a stronger risk for SJS/TEN with carbamazepine and oxcarbazepine, there is still a notable risk with lamot
Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory reaction syndrome caused by genetic or acquired immune dysregulation. The majority of adult HLH cases are caused by tumors, rheumatic immune disorders, and infections. However, drug-induced HLH is rarely reported.
View Article and Find Full Text PDFCurcumin protects against lamotrigine-induced chronic ovarian and uterine toxicity in rats by regulating PPAR-γ and ROS production.
J Biochem Mol Toxicol
January 2024
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Lamotrigine (LTG) is an antiepileptic drug with possible adverse effects on the female reproductive system. Curcumin was declared to improve ovarian performance. Therefore, this study aimed to clarify ovulatory dysfunction (OD) associated with LTG and the role of curcumin in ameliorating this dysfunction.
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