AI Article Synopsis
- The study explored how heparin/fibronectin (Hep/Fn) complexes can inhibit neointimal hyperplasia after endovascular procedures.
- Hep/Fn complexes were successfully attached to titanium surfaces and characterized using various methods, showing promising results.
- The findings indicate that these complexes can reduce smooth muscle cell proliferation, suggesting they could be effective new biomaterials for cardiovascular implants to prevent tissue growth issues.
Article Abstract
The aim of this study was to investigate the inhibitory effect of heparin/fibronectin (Hep/Fn) complexes on neointimal hyperplasia following endovascular intervention. Hep/Fn complexes were immobilized onto titanium (Ti) surfaces, with subsequent X-ray photoelectron spectroscopy (XPS), Toluidine Blue O (TBO) and immunohistochemistry methods were used to characterize surface properties. Smooth muscle cell (SMC) cultures were used to evaluate the effect of Hep/Fn complexes on SMC proliferation. Results showed that Hep/Fn complexes successfully immobilized onto Ti surfaces and resulted in an inhibition of SMC proliferation. This study suggests that Hep/Fn surface-immobilized biomaterials develop as a new generation of biomaterials to prevent neointimal hyperplasia, particularly for use in cardiovascular implants.
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| http://dx.doi.org/10.3967/bes2015.053 | DOI Listing |
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