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Non-secreting IL12 expressing oncolytic adenovirus Ad-TD-nsIL12 in recurrent high-grade glioma: a phase I trial.
Nat Commun
November 2024
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Malignant glioma is a highly fatal central nervous system malignancy with high recurrence rates. Oncolytic viruses offer potential treatment but need improvement in efficacy and safety. Here we describe a phase I, dose-escalating, single arm trial (ChiCTR2000032402) to study the safety of Ad-TD-nsIL12, an oncolytic adenovirus expressing non-secreting interleukin-12, in patients with recurrent high-grade glioma that connects with the ventricular system.
View Article and Find Full Text PDFIncidence of infection rate for shunt implantation: the zero % rate is always a myth.
Childs Nerv Syst
November 2024
Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.
Introduction: Paediatric CSF shunt infection rate remains a well-known complication that is not only responsible of potentially severe sequels for patients but also for economical expenses. In that study, we questioned if it is possible to attain the zero percent rate of infection that should be the goal of every paediatric neurosurgeon.
Methods: We report our series of patients treated with a CSF device from January the first 2016 to December 31 2018.
Ventriculo peritoneal shunted patient undergoing laparoscopic procedure - A case report and review of the literature.
Int J Surg Case Rep
October 2024
Department of Neurosurgery, B and B Hospital, Gwarko, Lalitpur, Nepal.
Introduction And Importance: It has been more than century since the establishment of relationship between the intracranial pressure (ICP) and intraabdominal pressure (IAP) was suspected and confirmed backed up by several studies. The studies clearly demonstrate a link and the positive correlation between the two.
Case Summary: 18 years old lady with previous history of ventricular peritoneal shunt during 6 months of age was planned for laparoscopic cholecystectomy.
Frontal bone resorption after fronto-facial monobloc advancement in FGFR-related craniosynostoses: predictive factors.
Plast Reconstr Surg
September 2024
Maxillo-facial surgery and Plastic surgery, Hôpital Necker - Enfants Malades, Assistance Publique Hôpitaux de Paris.
Background: Fronto-facial monobloc advancement with internal distraction (FFMBA) is a central procedure in the management of FGFR-related craniosynostoses. Children undergoing FFMBA may present with resorption of the frontal bony flap in the months or years following surgery. Here, we aimed at identifying the clinical factors associated with resorption and its extent in patients with Crouzon and Pfeiffer syndromes.
View Article and Find Full Text PDFUnveiling the domino effect: a nine-year follow-up on pentalogy of central nervous system induced by a large unruptured cerebral arteriovenous malformation: a case report and literature review.
Front Neurol
May 2024
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Background: The disruption of intracranial fluid dynamics due to large unruptured cerebral arteriovenous malformation (AVM) commonly triggers a domino effect within the central nervous system. This phenomenon is frequently overlooked in prior clinic and may lead to catastrophic misdiagnoses. Our team has documented the world's first case of so-called () induced by a AVM.
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