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Muscle Contractility in Hypokalemic Periodic Paralysis.
Muscle Nerve
December 2024
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Introduction/aims: Primary hypokalemic periodic paralysis (HypoPP) can present with periodic paralysis and/or permanent muscle weakness. Permanent weakness is accompanied by fat replacement of the muscle. It is unknown whether the permanent muscle weakness is solely due to fat replacement or if other factors affect the ability of the remaining muscle fibers to contract.
View Article and Find Full Text PDFIntroduction: Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but severe complication of hyperthyroidism characterized by acute muscle weakness. This study reports the first case of THPP in an adolescent with type 1 diabetes mellitus (T1DM) and Graves' disease, triggered by high-dose insulin, high carbohydrate intake, and strenuous exercise. It highlights the clinical presentation, management, and implications of THPP in this context.
View Article and Find Full Text PDFAcute Muscle Weakness in Graves' Disease: A Case Report of Hypokalemic Thyrotoxic Periodic Paralysis.
Cureus
November 2024
Emergency Medicine, Mayo Clinic Arizona, Phoenix, USA.
Thyrotoxic periodic paralysis (TPP) is a rare but significant complication of hyperthyroidism, characterized by episodes of muscle weakness or paralysis and associated hypokalemia. This case report details a 30-year-old Latin American male with a history of Graves' disease, presenting with acute muscle weakness and hypokalemia. The patient reported transient episodes of weakness over recent weeks, culminating in a severe episode prompting emergency evaluation.
View Article and Find Full Text PDFThyrotoxic Periodic Paralysis With Graves' Disease: A Case Report.
Cureus
November 2024
Emergency Medicine, Amrita Institute of Medical Sciences, Kochi, IND.
One type of hypokalemic periodic paralysis that is associated with hyperthyroidism is called thyrotoxic periodic paralysis (TPP). TPP can be linked to any cause of hyperthyroidism, although Graves' disease is the most common cause. This sporadic variant of hypokalaemic periodic paralysis, thyrotoxic periodic paralysis, is characterized by rapid onset weakness in the proximal muscles.
View Article and Find Full Text PDFQuantitative Muscle MRI to Monitor Disease Progression in Hypokalemic Period Paralysis.
Neurol Genet
December 2024
From the Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Article Synopsis
- Primary hypokalemic periodic paralysis (HypoPP) is a muscle condition that causes episodes of paralysis and can lead to permanent muscle weakness; understanding its natural progression could help in treatment evaluation.* -
- A study examined 37 individuals with HypoPP using MRI to measure fat replacement in muscles and strength tests to track changes over 20 months, revealing increased fat in many muscles but no significant muscle strength changes.* -
- The findings suggest that MRI is an effective tool for detecting subclinical progression of HypoPP, helping to assess disease progression in both symptomatic and asymptomatic patients.*
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