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Educating healthcare workers in snakebite management: A study to determine the effectiveness of the snake bite life support workshop.
Toxicon
January 2025
Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
Introduction: Snakebite envenomation is a significant global health issue, with India bearing a substantial burden. Despite the development of guidelines, knowledge gaps and lack of training persist among healthcare workers (HCWs), contributing to high morbidity and mortality. This study aimed to evaluate the impact of the Snake Bite Life Support (SBLS) workshop on HCWs' knowledge, practices, self-efficacy, and advocacy skills in snakebite management.
View Article and Find Full Text PDFQuantitative Ethnobotany of Medicinal Plants from Darjeeling District of West Bengal, India, along with Phytochemistry and Toxicity Study of Buch.-Ham. ex D.Don bark.
Plants (Basel)
December 2024
Ethnopharmacology Laboratory, Department of Botany, Visva-Bharati University, Santiniketan 731235, West Bengal, India.
This study offers considerable information on plant wealth of therapeutic importance used traditionally by the residents of 11 villages under three subdivisions of Kurseong, Darjeeling Sadar, and Mirik in the Darjeeling District, West Bengal. For the acquisition of ethnomedicinal information, semi-structured interviews were conducted with 47 informants, of whom 11 persons were herbalists and 36 were knowledgeable persons. Free prior informed consent was obtained from each participant prior to the collection of field data.
View Article and Find Full Text PDFBeyond Fang's fury: a computational study of the enzyme-membrane interaction and catalytic pathway of the snake venom phospholipase A toxin.
Chem Sci
January 2025
LAQV/Requimte, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, s/n 4169-007 Porto Portugal
Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.
View Article and Find Full Text PDFA rare case of acute myocardial infarction with heart failure following hump-nosed viper bite in a Sri Lankan female.
Trop Med Health
January 2025
Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Background: Hump-nosed viper (Hypnale species) bites are an important cause of mortality and morbidity in southern India and Sri Lanka, accounting for 27 and 77% of venomous snake bites, respectively. Previously, we knew them to be moderately venomous snakes, primarily causing local envenomation. However, recent reports have indicated severe systemic envenomation incidents, which include hemostatic dysfunction, microangiopathic hemolysis, kidney injury, myocardial toxicity, and even death.
View Article and Find Full Text PDFNational Action Plan for the prevention and control of snakebite envenoming in India: strategies and challenges.
Trans R Soc Trop Med Hyg
January 2025
Clinical Research Laboratory, ICMR- National Institute for Research in Reproductive and Child Health, J. M. Street, Parel, Mumbai, Maharashtra, India, 400012.
Article Synopsis
- India has the highest incidence of snakebite deaths globally, prompting the launch of a National Action Plan to combat this issue.
- The plan focuses on providing universal access to antivenom, improving healthcare, training professionals, and involving traditional healers to raise public awareness.
- It emphasizes collaboration across sectors, allows for state-specific strategies, and highlights the importance of ongoing political support, monitoring, global partnerships, and community engagement for successful implementation.
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