Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439577 | PMC |
| http://dx.doi.org/10.3389/fcell.2015.00030 | DOI Listing |
Publication Analysis
Top Keywords
protein disulphide
8
disulphide isomerase
8
disease states
8
novel roles
4
roles protein
4
isomerase disease
4
states double
4
double edged
4
edged sword?
4
sword? protein
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!