We report herein that Zn(II) selectively inhibits the hypoxia-inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5cc02143j | DOI Listing |
Publication Analysis
Top Keywords
hypoxia-inducible factor
8
factor prolyl
8
prolyl hydroxylase
8
hydroxylase phd3
8
phd3 znii
8
selective inhibition
4
inhibition hypoxia-inducible
4
znii
4
znii report
4
report znii
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!