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Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials. | LitMetric

AI Article Synopsis

  • - This study evaluates randomized controlled trials (RCTs) on the effects of Chinese Herbal Medicine (CHM) on health-related quality of life (HRQL) in patients with hypertension, specifically using the SF-36 questionnaire for assessment.
  • - Researchers analyzed data from 11 RCTs, involving 1,043 participants, but found that most studies had poor quality and showed significant variability in results; nevertheless, meta-analysis indicated that CHM improved both physical and mental health aspects of the SF-36 and reduced systolic blood pressure.
  • - The study concludes that while CHM may enhance HRQL in hypertensive patients, the results should be approached with caution and more high-quality clinical trials are necessary for reliable conclusions.

Article Abstract

Objectives: This study aims to evaluate published randomized controlled trials (RCTs) of Chinese Herbal Medicine (CHM) improving health-related quality of life (HRQL) in hypertensive patients that employ the Short-Form 36-Item Health questionnaire (SF-36) as an outcome measure.

Methods: Five electronic databases were searched up to October 2013 to identify RCTs of CHM for hypertension. The primary outcome was SF-36. Trial selection, data extraction, methodological quality assessment, and data analyses were conducted according to the Cochrane handbook.

Results: Eleven RCTs with total of 1043 participants were identified. The majority of the included trials were assessed to be of poor methodological quality and high clinical heterogeneity. Meta-analysis shows a significant improvement both in physical component summary (PCS) measure and mental component summary (MCS) measure of SF-36, with physical functioning (WMD=8.54[5.34, 11.74], p<0.001), role physical (WMD=13.32[7.03, 19.61], p<0.001), bodily pain (WMD=10.53[6.46, 14.60], p<0.001), general health (WMD=-5.56[2.09, 9.02], p<0.001), vitality (WMD=6.84[4.33, 9.53], p<0.001), social functioning (WMD=7.50[2.63, 12.36], p<0.001), role emotional (WMD=12.06[4.45, 19.68], p<0.001) and mental health (WMD=-5.68[2.90, 8.47], p<0.001). CHM can also decrease systolic blood pressure (WMD=-4.45 [-6.71, -2.19], p<0.001) and relieve symptoms related to hypertension.

Conclusions: CHM appears to have beneficial effects on improvement of HRQL in hypertensive patients. However, the findings should be interpreted with caution due to the poor methodological quality and high clinical heterogeneity of the included trials. Further clinical trials should be carried out to provide more reliable evidence.

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Source
http://dx.doi.org/10.1016/j.ctim.2015.04.002DOI Listing

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