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| http://dx.doi.org/10.1038/cdd.2015.64 | DOI Listing |
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GW0742 as a Potential TRα and TRβ Antagonist Reduces the Viability and Metabolic Activity of an Adult Granulosa Tumour Cell Line and Simultaneously Upregulates TRβ Expression.
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December 2024
Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland.
Background/objectives: Clinical studies have demonstrated a correlation between alterations in the expression level of TRα and TRβ receptors in ovarian cancer cells and overall survival. Celecoxib and GW0742, commonly known as a COX-2 inhibitor and a PPARβ/δ agonist, are novel thyroid hormone receptor antagonists that bind to TRβ or both TRα and TRβ.
Methods: The study was conducted on a non-luteinized ovarian granulosa cell line (HGrC1) and two rare ovarian cancer cell lines (COV434 and KGN).
A novel hyperactive variant of the transposase facilitates non-viral genome engineering.
Mol Ther Nucleic Acids
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Research Center, Division of Hematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Article Synopsis
- The SB transposon system is valuable for genetic applications like gene therapy, and a new hyperactive variant of the SB100X transposase, known as SB200X, was discovered with a specific amino acid change that increases its activity by about 2-fold.
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Stat3 Induces IL-10 and SR-A/CD204 Expression in Silica Nanoparticle-Triggered Pulmonary Fibrosis through Transactivation.
ACS Biomater Sci Eng
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Centre of Science and Society, Institute of Interdisciplinary Sciences (IIDS), University of Allahabad, Prayagraj 211002, India.
Inhalation of silica dust in the workplace has been addressed as a serious occupational pulmonary disease subsequently leading to inflammation and fibrosis. Enhanced expression of IL-10 significantly contributes to the disease etiology, along with an elevated Th2-type paradigm. Previously, we showed that the exaggerated Th2-type response was also associated with consistent upregulation of Stat3 in mouse airways stimulated with silica microparticles.
View Article and Find Full Text PDFSuper-Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription-Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer.
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Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200120, P. R. China.
Article Synopsis
- - Gallbladder cancer (GBC) is an aggressive cancer with no targeted therapies available, and this study focuses on super-enhancers (SEs), which are key regulatory elements driving cancerous gene expression.
- - Researchers analyzed genomic data from GBC samples to identify crucial transcription factors (TFs) SOX9 and TCF7L2, which interact to enhance each other's activity, leading to a specific and aggressive subtype of GBC linked to worse patient outcomes.
- - The study suggests that GBC patients with high levels of SOX9 and TCF7L2 may benefit from targeted therapies that inhibit CDK7, offering potential new treatment strategies for this difficult-to-treat cancer.
Exploring the molecular underpinnings of macrosomia in gestational diabetes mellitus: The role of EGFR signaling and placental syncytiotrophoblast.
Life Sci
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Department of Obstetrics, Obstetrics and Gynecology Center, The First Hospital of Jilin University, Jilin University, Changchun 130021, China. Electronic address:
Article Synopsis
- Macrosomia, often linked to gestational diabetes mellitus (GDM), indicates a significant relationship between maternal blood sugar levels and increased placental size, which plays a crucial role in nutrient transfer to the fetus.
- Our study utilized advanced single-cell RNA sequencing of placental tissues in cases of GDM complicated by macrosomia (GDMM) to identify specific cell subsets that influence placental growth.
- Key findings highlighted an upregulation of the epidermal growth factor receptor (EGFR) and its ligands, revealing complex interactions between placental cells and immune cells that could contribute to the development of macrosomia and suggest potential new therapies.
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