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Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis. | LitMetric

Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis.

Biochem Biophys Res Commun

Tianjin University, Department of Pharmaceutical Engineering, Tianjin 300072, China; Beijing Institute of Radiation Medicine, Beijing 100850, China; State Key Laboratory of Proteomics, Beijing 100850, China. Electronic address:

Published: July 2015

AI Article Synopsis

Article Abstract

Background & Aims: Hepassocin (HPS) is a hepatotrophic growth factor that specifically stimulates hepatocyte proliferation and promotes liver regeneration after liver damage. In this paper, zebrafish were used to investigate the role of HPS in liver development.

Methods And Results: During zebrafish development, HPS expression is enriched in liver throughout hepatogenesis. Knockdown of HPS using its specific morpholino leads to a smaller liver phenotype. Further results showed that the HPS knockdown has no effect on the expression of the early endoderm marker gata6 and early hepatic marker hhex. In addition, results showed that the smaller-liver phenotype in HPS morphants was caused by suppression of cell proliferation, not induction of cell apoptosis.

Conclusions: Current findings indicated that HPS is essential to the later stages of development in vertebrate liver organogenesis.

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Source
http://dx.doi.org/10.1016/j.bbrc.2015.05.121DOI Listing

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