AI Article Synopsis
- SHBG is a protein produced by the liver that binds sex hormones, influencing their availability in the body.
- Recent research indicates that liver fat content, rather than BMI, is a key factor affecting SHBG levels, challenging the traditional views on its regulation.
- The review also explores how inflammation may lower SHBG levels and considers the impact of diet on SHBG regulation, along with potential clinical implications and future research directions.
Article Abstract
Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause for low SHBG levels found in obesity. However, no mechanisms have ever been described. Emerging evidence now shows that liver fat content rather than BMI is a strong determinant of circulating SHBG. In this review we discuss evidence demonstrating that insulin might not regulate SHBG production, describe putative molecular mechanisms by which proinflammatory cytokines downregulate SHBG, and comment on recent findings suggesting dietary SHBG regulation. Finally, clinical implications of all of these findings and future perspectives are discussed.
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| http://dx.doi.org/10.1016/j.tem.2015.05.001 | DOI Listing |
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