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Research progress on ferroptosis regulation in tumor immunity of hepatocellular carcinoma.
Zhejiang Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Hepatobiliary and Pancreatic Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
Ferroptosis is a form of regulated cell death, which is dependent on iron metabolism imbalance and characterized by lipid peroxidation; it plays a crucial role in various pathological processes. Studies have shown that the occurrence of ferroptosis is closely associated with the progression of hepatocellular carcinoma (HCC). Ferroptosis is involved in regulating the lipid metabolism, iron homeostasis, mitochondrial metabolism, and redox processes in HCC.
View Article and Find Full Text PDFUnraveling the causal relationship between serum minerals and pancreatic cancer: a Mendelian randomization study.
Discov Oncol
December 2024
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Background: Pancreatic cancer is among the most lethal malignancies, characterized by a poor prognosis and limited modifiable factors. Emerging evidence indicates that serum mineral levels may influence the likelihood of developing pancreatic cancer. However, the causal relationship between serum minerals and pancreatic cancer remains unclear and warrants further investigation.
View Article and Find Full Text PDFMicronutrients and risk of gastroenteropancreatic neuroendocrine tumours: a Mendelian randomisation study.
Clin Nutr ESPEN
December 2024
Department of Oncology, Gansu Provincial Hospital, Lanzhou,73000,Gansu, China. Electronic address:
Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneousgroup of rare cancers. The effects of micronutrients on GEP-NETs have been explored in observational studies, but with inconsistent results. We conducted a two-sample Mendelian randomization (TSMR) study to investigate whether micronutrients influence the risk of GEP-NETs.
View Article and Find Full Text PDFBavachin stimulates ferroptosis and reduces malignant phenotype progression of hepatocellular carcinoma cells by inducing lipid peroxidation by modulation of the Nrf2/HO-1 signaling pathway.
Am J Transl Res
November 2024
Department of Hepatic Surgery IV, The Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University Shanghai 200438, The People's Republic of China.
Background: The mechanism of ferroptosis is primarily driven by the iron-dependent lethal accumulation of membrane lipid peroxidation. Bavachin has been found to exacerbate lipid peroxidation in cancer cells; however, whether it hinders hepatocellular carcinoma (HCC) progression by way of ferroptosis remains unknown.
Methods: Cell counting kit-8 (CCK-8) assay was used to measure the effect of Bavachin on the viability of HCC cells, so as to determine the appropriate drug concentration for subsequent experiments.
Complex Organ Injury Management in Abdominal Trauma: Case of a Heavy Iron Plate Accident.
Am J Case Rep
December 2024
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
BACKGROUND Open injury of multiple organs in the chest and abdomen, such as the colon, duodenum, kidney, liver and diaphragm, is relatively rare. The rescue of such a patient is difficult, and the results are often unsatisfactory. It is also a challenge for the hospital and doctors.
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