‐ ‐ The editorial group responsible for this previously published document have withdrawn it from publication.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666567 | PMC |
| http://dx.doi.org/10.1002/14651858.CD004193.pub3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of Quinidine-Induced Torsades de Pointes Risks Using a Whole-Body Physiologically Based Pharmacokinetic Model Linked to Cardiac Ionic Current Inhibition.
Clin Pharmacol Ther
March 2024
Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
The lethality of torsades de pointes (TdP) by drugs is one of main reasons that some drugs were withdrawn from the market. In order to assess drug-induced TdP risks, a model of cardiac ionic current suppression in human ventricular myocytes (ToR-ORd model), combined with the maximum effective free therapeutic plasma concentration or the maximum effective free therapeutic myocyte concentration was often used, with the latter proved to be more relevant and more accurate. We aimed to develop a whole-body physiologically-based pharmacokinetic (PBPK) model, incorporated with a human cardiomyocyte pharmacodynamic (PD) model, to provide a comprehensive assessment of drug-induced TdP risks in normal and specific scenarios.
View Article and Find Full Text PDFRational use of inhaled corticosteroids for the treatment of COPD: a plain language summary.
J Comp Eff Res
December 2023
National Heart & Lung Institute, Imperial College London, London, UK.
What Is This Summary About?: Inhaled corticosteroids (ICS) are a type of medication delivered via an inhaler device that are commonly used in the treatment of asthma. ICS can also be used to treat chronic obstructive pulmonary disease (COPD), a progressive respiratory condition in which the lungs become worse over time. However, unlike in asthma, ICS are only effective in a small proportion of people with COPD.
View Article and Find Full Text PDFClinical and Economic Impact of Long-Term Inhaled Corticosteroid Withdrawal in Patients with Chronic Obstructive Pulmonary Disease Treated with Triple Therapy in Spain.
Int J Chron Obstruct Pulmon Dis
September 2022
Medical Affairs, GlaxoSmithKline, Madrid, Spain.
Purpose: To determine the clinical and economic impact of inhaled corticosteroid (ICS) withdrawal in Spanish patients with COPD receiving triple therapy (TT) with ICS, long-acting β-agonist (LABA), and long-acting muscarinic antagonist (LAMA).
Patients And Methods: This was an observational, retrospective study of BIG-PAC database medical records. Patients aged ≥40 years receiving TT from 2016 to 2018 were followed for 1 year.
Short-acting inhaled bronchodilators for cystic fibrosis.
Cochrane Database Syst Rev
June 2022
Leeds Regional Paediatric Respiratory & Cystic Fibrosis Centre, A Floor, Clarendon Wing, Leeds Children's Hospital, Leeds, UK.
Background: Respiratory disease is the main cause of morbidity and mortality in cystic fibrosis (CF), and many different therapies are used by people with CF in the management of respiratory problems. Bronchodilator therapy is used to relieve symptoms of shortness of breath and to open the airways to allow clearance of mucus. Despite the widespread use of inhaled bronchodilators in CF, there is little objective evidence of their efficacy.
View Article and Find Full Text PDFAnalysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans.
Biomedicines
April 2022
Research and Development Department, IMG Pharma Biotech S.L, 48160 Derio, Spain.
Drug side effects are one of the main reasons for treatment withdrawal during clinical trials. Reactive oxygen species formation is involved in many of the drug side effects, mainly by interacting with the components of the cellular respiration. Thus, the early detection of these effects in the drug discovery process is a key aspect for the optimization of pharmacological research.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!