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Factors associated with abusive head trauma in young children presenting to emergency medical services using a large language model.
Prehosp Emerg Care
January 2025
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Objectives: Abusive head trauma (AHT) is a leading cause of death in young children. Analyses of patient characteristics presenting to Emergency Medical Services (EMS) are often limited to structured data fields. Artificial Intelligence (AI) and Large Language Models (LLM) may identify rare presentations like AHT through factors not found in structured data.
View Article and Find Full Text PDFMolecular epidemiology, evolution, and transmission dynamics of raccoon rabies virus in Connecticut.
Virus Evol
December 2024
Institute of Bioinformatics, University of Georgia, 120 Green St., Athens, GA 30602, United States.
In North America, raccoon rabies virus (RRV) is a public health concern due to its potential for rapid spread, maintenance in wildlife, and impact on human and domesticated animal health. RRV is an endemic zoonotic pathogen throughout the eastern USA. In 1991, an outbreak of RRV in Fairfield County, Connecticut, spread through the state and eventually throughout the Northeast and into Canada.
View Article and Find Full Text PDFMRPL24 drives breast cancer metastasis and stemness by targeting c-MYC, BRD4, and STAT3.
3 Biotech
February 2025
Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, University of Shanghai for Science and Technology, Shanghai, 200093 China.
Unlabelled: The study aims to investigate the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer (BC). Comprehensive bioinformatics analyses were conducted using data from The Cancer Genome Atlas (TCGA) and various advanced database, including cBioPortal, UALCAN, TIMER, Prognoscan, TISIDB, KM Plotter, and The Human Protein Atlas, to provide a detailed evaluation of MRPL55's role in cancer. The findings were further validated through experimental studies.
View Article and Find Full Text PDFResearch on unintroduced new drugs in South Korea from 2011 to 2020: approaches to prioritization and strategy.
Transl Clin Pharmacol
December 2024
Department of Clinical Pharmacology and Therapeutics, Dongguk University College of Medicine and Dongguk University Ilsan Hospital, Goyang 10326, Korea.
In recent years, with the experience of the COVID-19 pandemic, countries around the world have realized that improving patient access to new medicines can have a significant impact on public health and economic stability. The aim of this study was to identify new drugs that are urgently needed among those not yet available in South Korea from 2011 to 2020, and to develop strategies to improve access by analyzing the causes of delay. Through a 3-step screening process that included a literature review of new drugs, surveys of domestic clinicians and academics, and consideration of expedited review status by regulatory authorities, 34 out of 244 unreleased new drugs were prioritized for rapid introduction.
View Article and Find Full Text PDFPhysical Intimate Partner Violence Among Women Experiencing Homelessness Before and During Pregnancy.
Am J Epidemiol
January 2025
The Suzanne Dworak-Peck School of Social Work at the University of Southern California, Los Angeles, CA.
Intimate partner violence (IPV) and homelessness can have devastating health consequences for pregnant women. Using the Pregnancy Risk Assessment Monitoring System, we assessed differences in the association of physical IPV before and/or during pregnancy with adverse health outcomes between women experiencing homelessness (WEH) and domiciled women. Among 186,891 respondents, representing an estimated 11,489,161 women, 27.
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