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Platelet-rich plasma effects on in vitro cells derived from pediatric patients with andrological diseases.
Sci Rep
December 2024
Department of Neurosciences, Biomedicine and Movement Sciences, Biochemistry Section, University of Verona, Verona, Italy.
Undescended testis and testicular torsion represent two frequent andrological diseases that affect the pediatric age. Despite these testicular disorders having different causes, they both negatively influence fertility in adulthood mainly due to the accumulation of reactive oxygen species (ROS), which represents the primary molecular damage underlying their long-term effects. The gold standard of treatment for both pathologies is surgery; however, it cannot guarantee an optimal fertility outcome in all clinical cases, underscoring the need to identify effective adjuvant therapies that may target the augmented ROS levels.
View Article and Find Full Text PDFComparison of large single and small multiple doses of cyclophosphamide exposure in mice during early prepubertal age on fertility outcome.
Sci Rep
December 2024
Centre of Excellence in Clinical Embryology, Department of Reproductive Science, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, 576 104, India.
Cyclophosphamide (CY) exposure is known to affect the ovary and impair fertility. Clinically, treatment is generally given over multiple doses, but research models have generally used single doses. The relative effects of administering multiple small doses of CY in the prepubertal period are not elucidated.
View Article and Find Full Text PDFCryopreservation of ovarian cortex as fertility preservation in transgender men: A case report and literature review.
Int J Gynaecol Obstet
December 2024
Department of Surgery, Division of Urology, Human Reproduction Section, São Paulo Federal University (UNIFESP), São Paulo, Brazil.
Transgender people have been experiencing significant advancements in their social visibility, although they continue to face frequent discrimination and exclusion. Among the issues encompassing transgender individuals' health care, the right to reproductive and sexual health have gained traction in the study landscape, necessitating an exploration of fertility preservation options for these patients. This report sheds light on the process of cryopreserving gametes and ovarian tissue after total hysterectomy with bilateral salpingo-oophorectomy for gender reassignment in a transgender man in hormonal masculinization.
View Article and Find Full Text PDFCryopreserved sperm among patients with Oligoasthenoteratozoospermia.
Eur J Obstet Gynecol Reprod Biol
December 2024
Sperm Bank & Andrology Unit, Shamir Medical Center, Zerifin, Israel; IVF Department, Shamir Medical Center, Zerifin, Israel; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.
Objectives: This study investigates sperm utilization and disposal patterns in Oligoasthenoteratozoospermia (OAT) patients undergoing long-term sperm storage. OAT is a major contributor to male infertility. Cryopreservation is a common practice as a "fertility insurance" in case of further deterioration until azoospermia.
View Article and Find Full Text PDFTransrectal oocyte retrieval for fertility preservation in virginal women.
Reprod Biomed Online
October 2024
Virginia Center for Reproductive Medicine, Reston, VA, USA; Department of Obstetrics and Gynecology, George Washington University, Washington, DC, USA. Electronic address:
Research Question: How safe and effective is transrectal oocyte retrieval (TROR) for fertility preservation in nulliparous virginal women?
Design: This was a retrospective single-centre study of 105 nulliparous women from five satellite centres of Fakih IVF, UAE, who underwent TROR for oocyte cryopreservation. Extensive bowel preparation and rectal cleansing was performed prior to oocyte retrieval. Patient characteristics, stimulation protocol, and procedure outcome and safety data were collected.
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