Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Laminated Layer Extract from Echinococcus Granulosus cyst Attenuates Ocular Damages and Inflammatory Responses in an Experimental Autoimmune Uveitis Model.
Acta Parasitol
January 2025
Cytokines and NO Synthases Team, LBCM, FSB, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, 16111, Algeria.
Purpose: Since extract of the laminated layer (LL) from E. granulosus showed immuno-modulatory effects in vitro and in vivo, we sought to determine its effect on the onset, development, and evolution of experimental auto-immune uveitis (EAU). The latter is a model of some human diseases with ocular inflammation that can cause blindness.
View Article and Find Full Text PDFHerpes simplex virus type 2 in sub-Saharan Africa and the potential impact of helminth immune modulation.
Front Cell Infect Microbiol
December 2024
Department of Medical Microbiology, College of Health Sciences, School of Laboratory Medicine & Medical Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Herpes simplex virus type 2 (HSV-2) and helminth infections are among the most widespread infectious diseases in sub-Saharan Africa (SSA). Helminths are known to modulate host immune responses and consequently impact the severity and outcomes of unrelated diseases, including allergies, autoimmune conditions, and infectious diseases. In this way, helminths may modulate essential immune responses against HSV-2 during co-infection and may alter susceptibility to and pathology of HSV-2.
View Article and Find Full Text PDFAntigen B from Echinococcus granulosus regulates macrophage phagocytosis by controlling TLR4 endocytosis in immune thrombocytopenia.
Chem Biol Interact
January 2025
Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. Electronic address:
Immune thrombocytopenia (ITP) is characterized by a reduction in platelet counts, stemming from an autoimmune-mediated process where platelets are excessively cleared by macrophages. This enhanced phagocytosis is a cardinal pathogenic mechanism in ITP. Antigen B (AgB), a principal component of the Echinococcus granulosus cyst fluid, plays a pivotal role in safeguarding the parasite from host immune defenses by modulating macrophage activation.
View Article and Find Full Text PDFCathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages.
Int J Biol Macromol
January 2025
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, PR China. Electronic address:
Helminths can relieve the development of autoimmune diseases and inflammatory diseases, by inducing anti-inflammatory innate immune responses. Here, we report that CL7, a Cathepsin L protein secreted by Fasciola hepatica, inhibited the activation of the NF-κB and MAPK signaling resulting in reduced secretion of inflammatory mediators in macrophages. Furthermore，we found that CL7 could prevent dextran sulfate sodium (DSS) induced ulcerative colitis (UC).
View Article and Find Full Text PDFParasitic helminths and protozoa: Treasure boxes of disease modifying anti-rheumatic drugs.
Parasitol Int
April 2025
Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan.
Article Synopsis
- Parasites use various techniques to evade the host’s immune system, which can be beneficial in treating autoimmune and allergic diseases through a method known as "helminth therapy."
- Despite experimental evidence supporting the potential of parasites in combating autoimmune issues, like rheumatoid arthritis (RA), the exact mechanisms are not fully understood due to the variety of parasites and autoimmune disorders.
- This paper reviews how parasites can modulate the immune response, specifically their anti-arthritic effects, and explores the potential of using parasite-derived treatments as new options for managing RA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!