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Vacuum Insulated Probe Heated Electrospray Ionization Source Enhances Microflow Rate Chromatography Signals in the Bruker timsTOF Mass Spectrometer.
J Proteome Res
July 2023
Institute for Systems Biology, 401 Terry Avenue N, Seattle, Washington 98109, United States.
Article Synopsis
- The study highlights the importance of an efficient electrospray source for generating peptide molecular ions in liquid chromatography-mass spectrometry-based proteomics, focusing on a new technology called vacuum insulated probe heated electrospray ionization (VIP-HESI).
- VIP-HESI significantly enhances chromatography signals compared to traditional methods, leading to improved protein detection and quantitative precision in experiments, such as analyzing human K562 lymphoblast samples and mouse plasma.
- The technique allows for reliable identification of low peptide amounts, maintaining high reproducibility and coverage in proteomic applications, with supporting data available in a public database.
Microspray and microflow liquid chromatography: the way forward for LC-MS bioanalysis.
Bioanalysis
December 2017
Alturas Analytics, Inc. 1324 Alturas Drive Moscow, ID 83843, USA.
Microspray and microflow LC-MS/MS: the perfect fit for bioanalysis.
Bioanalysis
February 2016
New Objective, Inc., 2 Constitution Way, Woburn, MA 01801, USA.
Performance assessment of microflow LC combined with high-resolution MS in bioanalysis.
Bioanalysis
May 2013
Thermo Fisher Scientific, San Jose, CA, USA.
Background: There continues to be consistent pressure for bioanalytical scientists to achieve lower limits of quantitation. The reasons range from smaller sample volumes available for analysis, to more potent analytes and the growth of biologics in drug development. This has led scientists to investigate alternative LC techniques, including microflow and nanoflow.
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