Introduction: The purpose of this study was to evaluate the change in natural head position (NHP) after orthognathic surgery in skeletal Class III patients.
Methods: We used pretreatment (T1) and posttreatment (T2) cephalometric radiographs and T1 and T2 lateral facial photographs of 20 skeletal Class III patients (mean age, 21.6 years), with 20 skeletal Class I patients (mean age, 22.2 years) as the controls. The Class III patients had undergone mandibular setback surgery, and the patients in the control group had received conventional orthodontic treatment. All lateral facial photographs were recorded in NHP. The true vertical line (TVL) was transferred from the photograph to the cephalometric radiograph, and then the angle between the TVL and the Frankfort horizontal plane (TVL/FH) was measured. A t test and a paired t test were used to verify the differences between the 2 groups, and between the T1 and T2 measurements in each group.
Results: The mean TVL/FH at T1 was significantly greater in the Class III group than in the Class I group; this indicated that the Class III group showed head flexion. However, the mean TVL/FH of the Class III group decreased by -3.1° at T2; this indicated head extension, and it did not significantly differ from that of the Class I group. Nineteen of the 20 Class I patients showed minimal or no change in their TVL/FH (-1.5° to 1.5°) at T2. On the other hand, 6 of the 20 Class III patients showed more than a 4.5° decrease in their TVL/FH at T2.
Conclusions: Most of the Class I patients showed minimal or no change in their NHP at T2, but some Class III patients had changes in their NHP that tended toward head extension after mandibular setback surgery. Thus, soft tissue analysis using the TVL in NHP may not be reliable for some skeletal Class III patients who undergo mandibular setback surgery.
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http://dx.doi.org/10.1016/j.ajodo.2015.01.026 | DOI Listing |
Rheumatology (Oxford)
January 2025
The Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Objective: To explore the clinical characteristics and risk factors for adverse outcomes in patients with Sjögren's Syndrome-associated pulmonary arterial hypertension (SS-PAH).
Methods: A retrospective analysis was conducted on SS-PAH patients diagnosed by right heart catheterization (RHC) between March 2013 and March 2024 across four Chinese medical centers. Patients were categorized into primary SS-PAH (pSS-PAH) and overlap SS-PAH, based on the presence of additional autoimmune diseases.
Expert Opin Emerg Drugs
January 2025
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Introduction: Preclinical and clinical pharmacologic evidence indicate that orexin systems are relevant to sleep-wake cycle regulation and dimensions of reward and cognition, providing the basis to hypothesizing that they may be effective as therapeutics in mental disorders. Due to the limited efficacy and tolerability profiles of existing treatments for Major Depressive Disorder (MDD), investigational compounds in novel treatment classes are needed; seltorexant, an orexin receptor antagonist, is a potential new treatment currently under investigation.
Areas Covered: Mechanisms implicated in MDD, including reward and sleep are first overviewed.
Hum Cell
January 2025
Department of Nephrology, Zhong Da Hospital, Gulou District, No. 87, Dingjiaqiao, Zhongyangmen Street, Nanjing, 210009, Jiangsu, China.
Autophagy, a cellular degradation process involving the formation and clearance of autophagosomes, is mediated by autophagic proteins, such as microtubule-associated protein 1 light chain 3 (LC3) and sequestosome 1 (p62), and modulated by 3-methyladenine (3-MA) as well as chloroquine (CQ). Senescence, characterised by permanent cell cycle arrest, is marked by proteins such as cyclin-dependent kinase inhibitor 1 (p21) and tumour protein 53 (p53). This study aims to investigate the relationship between cell senescence and renal function in diabetic kidney disease (DKD) and the effect of autophagy on high-glucose-induced cell senescence.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.
The European Commission authorized the use of dried yellow mealworm (Tenebrio molitor - TM) as a food ingredient under Regulation EU 2021/882. As TM emerges as an important allergen source, sensitization and allergy to TM in various populations need investigation. The aim of this study was to assess the incidence of sensitization to TM before its introduction as a food ingredient in Poland, as well as checking the occurrence of co-sensitivity to TM and other invertebrate allergenic extracts and molecules.
View Article and Find Full Text PDFInt J Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Electronic address:
The aim of this study was to determine the effects of mandibular setback surgery exceeding 5 mm on upper airway and sleep quality in skeletal Class III patients, with comparisons to Class I controls. Sixteen individuals per group were selected based on their ANB angle and surgical need. 2D and 3D airway analyses were conducted.
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